What makes Blue O so special?
There is something fundamentally off-balance with the comsumption of drinks in our society. Many of us drink unbelieveably harmful beverages like softdrinks and energy drinks while the industry is massively educating us with positive information about exactly the drinks they sell you – it’s time to gradually change this status. 


We start now – Learn what makes Blue O so special!

Simply Said

Mate Tea is your healthy dose of extra power

Mate Tee – The healthy caffeine source

Mate tea contains natural caffeine together with more nutrients and two other stimulants found in coffee, tea, and chocolate: theophylline and theobromine (1). Caffeine blocks an inhibitory neurotransmitter called adenosine (2). This increases neuronal firing through production of dopamine and norepinephrine. The components of mate tea enhance mood, brain functions and improve memory (3).


The Acai berries are known to be rich in polyphenols (antioxidants), protecting the neurons from extremely dangerous radicals (4). According to a study made in Australia, the neuroprotective effects are further linked to a decreased risk of Alzheimer’s due to the inhibition of beta-amyloid proteins aggregation (5). Especially the antioxidant anthocyanin is abundant in acai berries with his anti-inflammatory and anti-cancerous properties (6).

Simply Said

Acai is the highway patrol for your brain routes

Simply Said

Ginseng provides Stamina in demanding times


The Ginsenoside content, the active components of Ginseng and the polysaccharides found in the roots make Ginseng so special in nutrition. The anti-fatigue effects of Ginseng polysaccharides have been reported in several studies (7). Ginseng is able to improve reaction time and accuracy, when enduring several cognitive tasks (8). Not only it has a healthy impact on alertness and relaxation, but also on appetite, cancer and fertility (9).


The Maca root, originates in Peru, is belonging to the broccoli family and is known to increase learning and being antidepressant (10). Further research also suggests that maca can improve cognitive ability in healthy people and even protect the brain from damage (11). Scientists of Newcastle have reported positive effects on enhanced physical performance and libido (12).

Simply Said

Maca is your personal Cheering Assisstant 

Simply Said

Glutamine supports the protective sphere for a healthy mind 


Glutamine is a conditionally essential amino acid, thus the need is higher during periods of physical/mental stress and disease (13). Glutamine is the most abundant amino acid in our body (10-15 times more concentrated in the brain) and plays a significant role in the glutamate/glutamine (GABA) cycle. Maintaining the cycle is important; a disruption can result in all kind of health problems (14). The synthesis of GABA helps to deal with stress, as it can give rise to inner calm and tranquility and the synthesis of glutamate, the most abundant excitatory neurotransmitter improves all kind of cognitive functions and neuronal plasticity. Through Glutamine the brain can get rid of excessive ammonia, which prevents restriction of normal brain functions and improves long and short term memory (15). For many cells, glutamine is often the preferred fuel source rather than glucose. Exogenous glutamine is one of the rare amino acids that can cross the blood-brain barrier. Glutamine is also a very effective intestinal and immune system health compound, thus cancer-protective (16).


L-Cartinine is an amino acid naturally found in meat and milk. A related compound, Acetyl-L-Carnitine (ALCAR) can be used as a brain booster, due to its ability to cross the blood-brain barrier and the neurological effects that comes with it (17). ALCAR contributes to the acetylcholine synthesis (18), as well as serotonine and noradrenaline, increasing alertness and alleviating neuronal decline and chronic fatigue. Further, a better availability of energy levels like glucose and creatine has been noted (19). ALCAR supplementation is also a safe way of improving cardiac health and protecting the cells from cancer-related functional impairment. ALCAR can provide support for the neurons through repairment of certain damage (20).

Simply Said

Acetyl-L-Cartinine is a natural talent in supporting memory capacity

Simply Said

Vitamin D3 is a natural super star for your personal health

Vitamin D3

Vitamin D3 is actually the precursor of a hormone, which our body produces from cholesterol when exposed to enough UVB light from sun (UV index 3 or higher, which only occurs close to the equator). The relation of low vitamin D3 levels with a high cancer risk is well studied and therefore many cancer drugs contain Vitamin D3 (21). Most people lack an optimal level of vitamin D3, especially in regions further away from equator (North America, Europe, Asia-pacific countries) (22). Supplementation of Vitamin D3 has a wide range of benefits other than reducing the risks of cancer, improving significantly well-being and many aspects of health (23). Studies suggest that Vitamin D3 enhance cognitive functions like non-verbal memory (24) and protects neurons from diseases like Multiple Sclerosis, Alzheimer’s, and Parkinson’s (25).

Citric Acid

Citric Acid is commonly used as a natural acidifier, flavoring and preservative in food and drinks. Citric acid acts as an antioxidant, preventing oxidative stress and inflammation in the brain (26). It shows also antimicrobial activity, therefore helps to get rid of bacteria, viruses (27).

Simply Said

Citrid acid is getting rid of unwanted stuff 

Simply Said

Agave is a natural sugar substitute to reduce root bitterness

Agave Syrup

Agave syrup is made from the Agave plant, growing in Mexico and known as the “Tequila plant”. It is a natural sweetener and compared to other sugars, it is high in fructose (28) and has a low glycemic index (GI), which will increase sugar levels slowly and not in one sharp peek. This has a positive effect on insulin sensitivity and weight (29).


Primarily, magnesium serves as an electrolyte or is involved in regulating enzymes in the body. In the brain, magnesium helps regulating the firing of neurons while occupying the calcium receptors when the neuron is “resting” (30). In this way it prevents the brain from neurotoxicity, helps with migraines, ADHD, depression and sleep. Also, higher levels of magnesium in brain support greater signaling and lead to the enhancements of synaptic plasticity as well as learning and memory. However, despite its importance, studies show that almost 50% of people in Western countries in Europe and the United States don’t get enough of this essential mineral (31/32) .

Simply Said

Not having enough Magnesium means not Properly working Body Functions

Simply Said

Zinc is an essential micronutrient that is crucial to almost every aspect of your health.


Zinc is one essential minerals commonly used to support the immune system to be less affected to illness (33). Zinc also plays the role of a neuromodulator in the hippocampus and in the pineal gland and is released from neuronal synapses when signaling (34). It increases serotonin uptake and helps in activating a protein in the brain called BDNF, which plays a role in neuronal growth and plasticity (35).

Vitamin B12 and Folic Acid

Folic Acid is the synthetic form of folate (vitamin B9) and is usually supplemented together with Vitamin B12 due to their complementary enzymatic roles in the cell like DNA, neurotransmitter and antioxidant synthesis. The intake of Cobalamin (Vitamin B12) and folate has strong neurological effects (36). High vitamin B12/ folate levels have shown to prevent people to suffer from depression and stroke (37).

Simply Said

These two Heros help to produce and maintain new cells like blood cells, your body’s fuel system

Simply Said

Vitamin C, also known as ascorbic acid, is necessary for the growth, development and repair of all body tissues. Any QUestions?

Vitamin C

Vitamin C is known for his strong antioxidant properties, thus used to strengthen the immune system (38). This antioxidant property means Vitamin C provides protection against neurodegenerative diseases, stress and neuronal degradation (39). Also vitamin C is a cofactor for the synthesis of neurotransmitter and hormones. Researchers have described how high doses of vitamin C can potentially kill cancer (40).


Pomegranate contains small seeds called “arids”, in which the anti-oxidant Punicalagin components and important proteins are water-soluble (41). Punicalagin helps prevent oxidative stress and reduces inflammation throughout the body (42). A clinical trial have successfully applied pomegranate to deal with prostate cancer (43).

Simply Said

Super tasty and super healthy

Simply Said

Drink awesome berries with Blue O

Blueberry/Bilberry/Cranberry juice

All three fruits blueberry, bilberry and cranberry belong to the same genus vaccinium. They contain antioxidants and anthocyanins, which make them highly effective at reducing cognitive decline associated with age and protecting the liver from fat buildup (44). The nootropic effect is equally observed in young individuals. Blueberries are reducing inflammation in neurons as they reduce the release of inflammatory cytokines (45).

Sources :

1. Heck, C., & de Mejia, E. (2007). Yerba Mate Tea (Ilex paraguariensis): A Comprehensive Review on Chemistry, Health Implications, and Technological Considerations. Journal Of Food Science, 72(9), R138-R151. / 2. Franco, R., Oñatibia-Astibia, A., & Martínez-Pinilla, E. (2018). Health Benefits of Methylxanthines in Cacao and Chocolate. / 3. Nehlig A, e. (2018). Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. – PubMed – NCBI. / 4. Sadowska-Krępa, E., Kłapcińska, B., Podgórski, T., Szade, B., Tyl, K., & Hadzik, A. (2014). Effects of supplementation with acai (Euterpe oleracea Mart.) berry-based juice blend on the blood antioxidant defence capacity and lipid profile in junior hurdlers. A pilot study. Biology Of Sport, 32(2), 161-168. / 5. Wong, D., Musgrave, I., Harvey, B., & Smid, S. (2013). Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro. Neuroscience Letters, 556, 221-226. / 6. Anthocyanins. (2018). Retrieved from http://www.todaysdietitian.com/newarchives/030314p20.shtml/ 7. Wong, D., Musgrave, I., Harvey, B., & Smid, S. (2013). Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro. Neuroscience Letters, 556, 221-226./ 8. Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. (2005)/ 9. Wiklund, I., Karlberg, J., & Lund, B. (1994). A double-blind comparison of the effect on quality of life of a combination of vital substances including standardized ginseng G115 and placebo. Current Therapeutic Research, 55(1), 32-42./ 10. Rubio, J., Caldas, M., Dávila, S., Gasco, M., & Gonzales, G. (2006). Effect of three different cultivars of Lepidium meyenii (Maca) on learning and depression in ovariectomized mice. BMC Complementary And Alternative Medicine, 6(1)./ 11. Pino-Figueroa, A., Nguyen, D., & Maher, T. (2010). Neuroprotective effects of Lepidium meyenii (Maca). Annals Of The New York Academy Of Sciences, 1199(1), 77-85./ 12. Stone, M., Ibarra, A., Roller, M., Zangara, A., & Stevenson, E. (2009). A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. Journal Of Ethnopharmacology, 126(3), 574-576./ 13. Lacey, J., & Wilmore, D. (2009). Is Glutamine a Conditionally Essential Amino Acid?. Nutrition Reviews, 48(8), 297-309./ 14. Neu, J., Shenoy, V., & Chakrabarti, R. (1996). Glutamine nutrition and metabolism: where do we go from here ?. The FASEB Journal, 10(8), 829-837./ 15. McEntee, W., & Crook, T. (1993). Glutamate: its role in learning, memory, and the aging brain. Psychopharmacology, 111(4), 391-401./ 16. Dutta, S., Ray, S., & Nagarajan, K. (2013). Glutamic acid as anticancer agent: An overview. Saudi Pharmaceutical Journal, 21(4), 337-343./ 17. Parnetti, L., Gaiti, A., Mecocci, P., Cadini, D., & Senin, U. (1993). Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type. European Journal of Clinical Pharmacology, 44(6), 604-604./ 18. Dolezal, V., & Tucek, S. (1981, April). Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices./ 19. Smeland, O. B., Meisingset, T. W., Borges, K., & Sonnewald, U. (2012, July). Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice./ 20. Dhitavat, S., Ortiz, D., Shea, T. B., & Rivera, E. R. (2002, June). Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: Roles of oxidative buffering and ATP levels./ 21. Grant, W. B., & Holick, M. F. (2005, June). Benefits and requirements of vitamin D for optimal health: A review./ 22. Whiting, S. J., Green, T. J., & Calvo, M. S. (2007). Vitamin D intakes in North America and Asia-Pacific countries are not sufficient to prevent vitamin D insufficiency. The Journal of Steroid Biochemistry and Molecular Biology,103(3-5), 626-630./ 23. Vieth, R. (1999). Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. The American Journal of Clinical Nutrition,69(5), 842-856./ 24. Pettersen, J. A. (2017). Does high dose vitamin D supplementation enhance cognition?: A randomized trial in healthy adults. Experimental Gerontology,90, 90-97./ 25. Salzer, J., Hallmans, G., Nystrom, M., Stenlund, H., Wadell, G., & Sundstrom, P. (2012). Vitamin D as a protective factor in multiple sclerosis. Neurology,79(21), 2140-2145./ 26. Abdel-Salam, O. M., Youness, E. R., Mohammed, N. A., Morsy, S. M., Omara, E. A., & Sleem, A. A. (2014). Citric Acid Effects on Brain and Liver Oxidative Stress in Lipopolysaccharide-Treated Mice. Journal of Medicinal Food, 17(5), 588-598./ 27. Georgopoulou, M., et al. “Evaluation of the Antimicrobial Effectiveness of Citric Acid and Sodium Hypochlorite on the Anaerobic Flora of the Infected Root Canal.” International Endodontic Journal, vol. 27, no. 3, 1994, pp. 139–143./ 28. Willems, Jamie L., and Nicholas H. Low. “Major Carbohydrate, Polyol, and Oligosaccharide Profiles of Agave Syrup. Application of This Data to Authenticity Analysis.” Journal of Agricultural and Food Chemistry, vol. 60, no. 35, 2012, pp. 8745–8754./ 29. Hooshmand, Shirin, et al. “Effects of Agave Nectar Versus Sucrose on Weight Gain, Adiposity, Blood Glucose, Insulin, and Lipid Responses in Mice.” Journal of Medicinal Food, vol. 17, no. 9, 2014, pp. 1017–1021./ 30. Nowak, L., et al. “Magnesium Gates Glutamate-Activated Channels in Mouse Central Neurones.” Nature, vol. 307, no. 5950, 1984, pp. 462–465./ 31. Slutsky, Inna, et al. “Enhancement of Learning and Memory by Elevating Brain Magnesium.” Neuron, vol. 65, no. 2, 2010, pp. 165–177./ 32. Abumaria, N., et al. “Effects of Elevation of Brain Magnesium on Fear Conditioning, Fear Extinction, and Synaptic Plasticity in the Infralimbic Prefrontal Cortex and Lateral Amygdala.” Journal of Neuroscience, vol. 31, no. 42, 2011, pp. 14871–14881./ 33. Prasad, Ananda S, et al. “Zinc Supplementation Decreases Incidence of Infections in the Elderly: Effect of Zinc on Generation of Cytokines and Oxidative Stress.” The American Journal of Clinical Nutrition, vol. 85, no. 3, Jan. 2007, pp. 837–844./ 34. Charton, G., et al. “Spontaneous and Evoked Release of Endogenous Zn2 in the Hippocampal Mossy Fiber Zone of the Rat in Situ.” Experimental Brain Research, vol. 58, no. 1, 1985/ 35. Corona, C, et al. “Dietary Zinc Supplementation of 3xTg-AD Mice Increases BDNF Levels and Prevents Cognitive Deficits as Well as Mitochondrial Dysfunction.” Cell Death & Disease, vol. 1, no. 10, 2010/ 36. Reynolds, Edward. “Vitamin B12, Folic Acid, and the Nervous System.” The Lancet Neurology, vol. 5, no. 11, 2006, pp. 949–960./ 37. Hintikka, Jukka, et al. “High Vitamin B12 Level and Good Treatment Outcome May Be Associated in Major Depressive Disorder.” BMC Psychiatry, vol. 3, no. 1, 2003/ 38. Moretti, Morgana, et al. “Protective Effects of Ascorbic Acid on Behavior and Oxidative Status of Restraint-Stressed Mice.” Journal of Molecular Neuroscience, vol. 49, no. 1, Mar. 2012, pp. 68–79./ 39. Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? (2017). Nutrients, 9(7), 659./ 40. Yun, J., Mullarky, E., Lu, C., Bosch, K. N., Kavalier, A., Rivera, K., Cantley, L. C. (2015, December 11). Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH./ 41. Yang, H., Li, M., Qi, X., Lv, C., Deng, J., & Zhao, G. (2012). Identification of seven water-soluble non-storage proteins from pomegranate (Punica granatum Linn.) seeds. Food Science and Technology International, 18(4), 329-338./ 42. Wang, Y., Huang, M., Yang, X., Yang, Z., Li, L., & Mei, J. (2018). Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension. The Korean Journal of Physiology & Pharmacology, 22(4), 409./ 43. Pantuck, A. J. (2006). Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer. Clinical Cancer Research, 12(13), 4018-4026./ 44. Coultrap, S. J., Bickford, P. C., & Browning, M. D. (2008). Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP. Age,30(4), 263-272./ 45. Lau, F. C., Bielinski, D. F., & Joseph, J. A. (2007). Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. Journal of Neuroscience Research, 85(5), 1010-1017.